Velakast tablets” (sofosbuvir 400mg & Velpatasvir 100mg) – VelaKast is a tablet with a fixed dose and comprising sofosbuvir velpatasvir for oral administration. Sofosbuvir is the nucleotide analog of the NS5B HCV polymerase inhibitor, and velpatasvir is an NS5A inhibitor. Each tablet contains 400 mg of sofosbuvir and 100 mg of velpatasvir. Tablets include the following inactive ingredients: croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are coated with a coating film containing the following inactive ingredients: IP titanium dioxide and diamond blue FCF, polyethylene glycol, polyvinyl alcohol, talc and titanium dioxide. Velacast (sofosbuvir 400mg & Velpatasvir 100mg) – VelaKast reviews are very good
Mechanism of action
VELAKAST is a fixed-dose combination and sofosbuvir velpatasvir, antiviral agents that are direct action against the virus of hepatitis C. sofosbuvir is an inhibitor of RNA dependent RNA HCV NS5B polymerase required for viral replication. Sofosbuvir represents a nucleotide prodrug that undergoes intracellular metabolized to pharmacologically active analog uridine-triphosphate (GS-461 203) which may be included in the HCV RNA by a polymerase and NS5B acts as a chain terminator. The biochemical analysis of GS-461203 inhibited the polymerase activity of recombinant NS5B from genotype 1b, 2a, 3a and 4a HCV with an IC50 value ranging from 0.36 to 3.3 micromolar. GS-461203 is neither an inhibitor of human DNA DNA and RNA polymerases nor a mitochondrial RNA polymerase inhibitor. Velpatasvir is an inhibitor of HCV NS5A protein, which is required for viral replication. The selection of resistance in cell culture studies and cross-resistance indicates that the NS5A Vegeta-virgin target is its mode of action.
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